Synergistic Combination of Oncolytic Virotherapy and Immunotherapy for Glioma.
Identifieur interne : 000040 ( Main/Exploration ); précédent : 000039; suivant : 000041Synergistic Combination of Oncolytic Virotherapy and Immunotherapy for Glioma.
Auteurs : Bingtao Tang [États-Unis] ; Zong Sheng Guo [États-Unis] ; David L. Bartlett [États-Unis] ; David Z. Yan [États-Unis] ; Claire P. Schane [États-Unis] ; Diana L. Thomas [États-Unis] ; Jia Liu [États-Unis] ; Grant Mcfadden [États-Unis] ; Joanna L. Shisler [États-Unis] ; Edward J. Roy [États-Unis]Source :
- Clinical cancer research : an official journal of the American Association for Cancer Research [ 1078-0432 ] ; 2020.
Abstract
PURPOSE
We hypothesized that the combination of a local stimulus for activating tumor-specific T cells and an anti-immunosuppressant would improve treatment of gliomas. Virally encoded IL15Rα-IL15 as the T-cell activating stimulus and a prostaglandin synthesis inhibitor as the anti-immunosuppressant were combined with adoptive transfer of tumor-specific T cells.
EXPERIMENTAL DESIGN
Two oncolytic poxviruses, vvDD vaccinia virus and myxoma virus, were each engineered to express the fusion protein IL15Rα-IL15 and a fluorescent protein. Viral gene expression (YFP or tdTomato Red) was confirmed in the murine glioma GL261
RESULTS
vvDD-IL15Rα-YFP and vMyx-IL15Rα-tdTr each infected and killed GL261 cells
CONCLUSIONS
IL15Rα-IL15-armed oncolytic poxviruses provide potent antitumor effects against brain tumors when combined with adoptive T-cell therapy, rapamycin, and celecoxib.
DOI: 10.1158/1078-0432.CCR-18-3626
PubMed: 32019860
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Synergistic Combination of Oncolytic Virotherapy and Immunotherapy for Glioma.</title><author><name sortKey="Tang, Bingtao" sort="Tang, Bingtao" uniqKey="Tang B" first="Bingtao" last="Tang">Bingtao Tang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana</wicri:cityArea></affiliation></author><author><name sortKey="Guo, Zong Sheng" sort="Guo, Zong Sheng" uniqKey="Guo Z" first="Zong Sheng" last="Guo">Zong Sheng Guo</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Bartlett, David L" sort="Bartlett, David L" uniqKey="Bartlett D" first="David L" last="Bartlett">David L. Bartlett</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Yan, David Z" sort="Yan, David Z" uniqKey="Yan D" first="David Z" last="Yan">David Z. Yan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana</wicri:cityArea></affiliation></author><author><name sortKey="Schane, Claire P" sort="Schane, Claire P" uniqKey="Schane C" first="Claire P" last="Schane">Claire P. Schane</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana</wicri:cityArea></affiliation></author><author><name sortKey="Thomas, Diana L" sort="Thomas, Diana L" uniqKey="Thomas D" first="Diana L" last="Thomas">Diana L. Thomas</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pathology, The Ohio State University Wexner Medical Center, Columbus</wicri:cityArea></affiliation></author><author><name sortKey="Liu, Jia" sort="Liu, Jia" uniqKey="Liu J" first="Jia" last="Liu">Jia Liu</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arkansas</region></placeName><wicri:cityArea>Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock</wicri:cityArea></affiliation></author><author><name sortKey="Mcfadden, Grant" sort="Mcfadden, Grant" uniqKey="Mcfadden G" first="Grant" last="Mcfadden">Grant Mcfadden</name><affiliation wicri:level="2"><nlm:affiliation>Biodesign Institute, Arizona State University, Tempe, Arizona.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Biodesign Institute, Arizona State University, Tempe</wicri:cityArea></affiliation></author><author><name sortKey="Shisler, Joanna L" sort="Shisler, Joanna L" uniqKey="Shisler J" first="Joanna L" last="Shisler">Joanna L. Shisler</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, University of Illinois Urbana-Champaign, Urbana, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Microbiology, University of Illinois Urbana-Champaign, Urbana</wicri:cityArea></affiliation></author><author><name sortKey="Roy, Edward J" sort="Roy, Edward J" uniqKey="Roy E" first="Edward J" last="Roy">Edward J. Roy</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, Illinois. eroy@illinois.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32019860</idno><idno type="pmid">32019860</idno><idno type="doi">10.1158/1078-0432.CCR-18-3626</idno><idno type="wicri:Area/Main/Corpus">000126</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000126</idno><idno type="wicri:Area/Main/Curation">000126</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000126</idno><idno type="wicri:Area/Main/Exploration">000126</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Synergistic Combination of Oncolytic Virotherapy and Immunotherapy for Glioma.</title><author><name sortKey="Tang, Bingtao" sort="Tang, Bingtao" uniqKey="Tang B" first="Bingtao" last="Tang">Bingtao Tang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana</wicri:cityArea></affiliation></author><author><name sortKey="Guo, Zong Sheng" sort="Guo, Zong Sheng" uniqKey="Guo Z" first="Zong Sheng" last="Guo">Zong Sheng Guo</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Bartlett, David L" sort="Bartlett, David L" uniqKey="Bartlett D" first="David L" last="Bartlett">David L. Bartlett</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Yan, David Z" sort="Yan, David Z" uniqKey="Yan D" first="David Z" last="Yan">David Z. Yan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana</wicri:cityArea></affiliation></author><author><name sortKey="Schane, Claire P" sort="Schane, Claire P" uniqKey="Schane C" first="Claire P" last="Schane">Claire P. Schane</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana</wicri:cityArea></affiliation></author><author><name sortKey="Thomas, Diana L" sort="Thomas, Diana L" uniqKey="Thomas D" first="Diana L" last="Thomas">Diana L. Thomas</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pathology, The Ohio State University Wexner Medical Center, Columbus</wicri:cityArea></affiliation></author><author><name sortKey="Liu, Jia" sort="Liu, Jia" uniqKey="Liu J" first="Jia" last="Liu">Jia Liu</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arkansas</region></placeName><wicri:cityArea>Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock</wicri:cityArea></affiliation></author><author><name sortKey="Mcfadden, Grant" sort="Mcfadden, Grant" uniqKey="Mcfadden G" first="Grant" last="Mcfadden">Grant Mcfadden</name><affiliation wicri:level="2"><nlm:affiliation>Biodesign Institute, Arizona State University, Tempe, Arizona.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Biodesign Institute, Arizona State University, Tempe</wicri:cityArea></affiliation></author><author><name sortKey="Shisler, Joanna L" sort="Shisler, Joanna L" uniqKey="Shisler J" first="Joanna L" last="Shisler">Joanna L. Shisler</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, University of Illinois Urbana-Champaign, Urbana, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Microbiology, University of Illinois Urbana-Champaign, Urbana</wicri:cityArea></affiliation></author><author><name sortKey="Roy, Edward J" sort="Roy, Edward J" uniqKey="Roy E" first="Edward J" last="Roy">Edward J. Roy</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, Illinois. eroy@illinois.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana</wicri:cityArea></affiliation></author></analytic><series><title level="j">Clinical cancer research : an official journal of the American Association for Cancer Research</title><idno type="ISSN">1078-0432</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>PURPOSE</b></p><p>We hypothesized that the combination of a local stimulus for activating tumor-specific T cells and an anti-immunosuppressant would improve treatment of gliomas. Virally encoded IL15Rα-IL15 as the T-cell activating stimulus and a prostaglandin synthesis inhibitor as the anti-immunosuppressant were combined with adoptive transfer of tumor-specific T cells.</p></div><div type="abstract" xml:lang="en"><p><b>EXPERIMENTAL DESIGN</b></p><p>Two oncolytic poxviruses, vvDD vaccinia virus and myxoma virus, were each engineered to express the fusion protein IL15Rα-IL15 and a fluorescent protein. Viral gene expression (YFP or tdTomato Red) was confirmed in the murine glioma GL261 </p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>vvDD-IL15Rα-YFP and vMyx-IL15Rα-tdTr each infected and killed GL261 cells </p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>IL15Rα-IL15-armed oncolytic poxviruses provide potent antitumor effects against brain tumors when combined with adoptive T-cell therapy, rapamycin, and celecoxib.</p></div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">32019860</PMID><DateRevised><Year>2020</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1078-0432</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>9</Issue><PubDate><Year>2020</Year><Month>May</Month><Day>01</Day></PubDate></JournalIssue><Title>Clinical cancer research : an official journal of the American Association for Cancer Research</Title><ISOAbbreviation>Clin Cancer Res</ISOAbbreviation></Journal><ArticleTitle>Synergistic Combination of Oncolytic Virotherapy and Immunotherapy for Glioma.</ArticleTitle><Pagination><MedlinePgn>2216-2230</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1158/1078-0432.CCR-18-3626</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">We hypothesized that the combination of a local stimulus for activating tumor-specific T cells and an anti-immunosuppressant would improve treatment of gliomas. Virally encoded IL15Rα-IL15 as the T-cell activating stimulus and a prostaglandin synthesis inhibitor as the anti-immunosuppressant were combined with adoptive transfer of tumor-specific T cells.</AbstractText><AbstractText Label="EXPERIMENTAL DESIGN" NlmCategory="METHODS">Two oncolytic poxviruses, vvDD vaccinia virus and myxoma virus, were each engineered to express the fusion protein IL15Rα-IL15 and a fluorescent protein. Viral gene expression (YFP or tdTomato Red) was confirmed in the murine glioma GL261 <i>in vitro</i> and <i>in vivo</i>. GL261 tumors in immunocompetent C57BL/6J mice were treated with vvDD-IL15Rα-YFP vaccinia virus or vMyx-IL15Rα-tdTr combined with other treatments, including vaccination with GARC-1 peptide (a neoantigen for GL261), rapamycin, celecoxib, and adoptive T-cell therapy.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">vvDD-IL15Rα-YFP and vMyx-IL15Rα-tdTr each infected and killed GL261 cells <i>in vitro</i>. <i>In vivo</i>, NK cells and CD8<sup>+</sup> T cells were increased in the tumor due to the expression of IL15Rα-IL15. Each component of a combination treatment contributed to prolonging survival: an oncolytic virus, the IL15Rα-IL15 expressed by the virus, a source of T cells (whether by prevaccination or adoptive transfer), and prostaglandin inhibition all synergized to produce elimination of gliomas in a majority of mice. vvDD-IL15Rα-YFP occasionally caused ventriculitis-meningitis, but vMyx-IL15Rα-tdTr was safe and effective, causing a strong infiltration of tumor-specific T cells and eliminating gliomas in 83% of treated mice.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">IL15Rα-IL15-armed oncolytic poxviruses provide potent antitumor effects against brain tumors when combined with adoptive T-cell therapy, rapamycin, and celecoxib.</AbstractText><CopyrightInformation>©2020 American Association for Cancer Research.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Bingtao</ForeName><Initials>B</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-7011-7381</Identifier><AffiliationInfo><Affiliation>Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, Illinois.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Zong Sheng</ForeName><Initials>ZS</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-4624-9907</Identifier><AffiliationInfo><Affiliation>Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bartlett</LastName><ForeName>David L</ForeName><Initials>DL</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yan</LastName><ForeName>David Z</ForeName><Initials>DZ</Initials><AffiliationInfo><Affiliation>Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, Illinois.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schane</LastName><ForeName>Claire P</ForeName><Initials>CP</Initials><AffiliationInfo><Affiliation>Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, Illinois.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thomas</LastName><ForeName>Diana L</ForeName><Initials>DL</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-7004-2036</Identifier><AffiliationInfo><Affiliation>Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Jia</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McFadden</LastName><ForeName>Grant</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Biodesign Institute, Arizona State University, Tempe, Arizona.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shisler</LastName><ForeName>Joanna L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Department of Microbiology, University of Illinois Urbana-Champaign, Urbana, Illinois.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roy</LastName><ForeName>Edward J</ForeName><Initials>EJ</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-3480-3699</Identifier><AffiliationInfo><Affiliation>Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, Illinois. eroy@illinois.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>K22 AI099184</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI139106</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>02</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Clin Cancer Res</MedlineTA><NlmUniqueID>9502500</NlmUniqueID><ISSNLinking>1078-0432</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>11</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>12</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>01</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>2</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>2</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>2</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32019860</ArticleId><ArticleId IdType="pii">1078-0432.CCR-18-3626</ArticleId><ArticleId IdType="doi">10.1158/1078-0432.CCR-18-3626</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Arizona</li><li>Arkansas</li><li>Illinois</li><li>Ohio</li><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Tang, Bingtao" sort="Tang, Bingtao" uniqKey="Tang B" first="Bingtao" last="Tang">Bingtao Tang</name></region><name sortKey="Bartlett, David L" sort="Bartlett, David L" uniqKey="Bartlett D" first="David L" last="Bartlett">David L. Bartlett</name><name sortKey="Guo, Zong Sheng" sort="Guo, Zong Sheng" uniqKey="Guo Z" first="Zong Sheng" last="Guo">Zong Sheng Guo</name><name sortKey="Liu, Jia" sort="Liu, Jia" uniqKey="Liu J" first="Jia" last="Liu">Jia Liu</name><name sortKey="Mcfadden, Grant" sort="Mcfadden, Grant" uniqKey="Mcfadden G" first="Grant" last="Mcfadden">Grant Mcfadden</name><name sortKey="Roy, Edward J" sort="Roy, Edward J" uniqKey="Roy E" first="Edward J" last="Roy">Edward J. Roy</name><name sortKey="Schane, Claire P" sort="Schane, Claire P" uniqKey="Schane C" first="Claire P" last="Schane">Claire P. Schane</name><name sortKey="Shisler, Joanna L" sort="Shisler, Joanna L" uniqKey="Shisler J" first="Joanna L" last="Shisler">Joanna L. Shisler</name><name sortKey="Thomas, Diana L" sort="Thomas, Diana L" uniqKey="Thomas D" first="Diana L" last="Thomas">Diana L. Thomas</name><name sortKey="Yan, David Z" sort="Yan, David Z" uniqKey="Yan D" first="David Z" last="Yan">David Z. Yan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000040 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000040 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= RapamycinFungusV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32019860
|texte= Synergistic Combination of Oncolytic Virotherapy and Immunotherapy for Glioma.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32019860" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a RapamycinFungusV1
| This area was generated with Dilib version V0.6.38. |  |